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1B-LSD
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Chemical compound
1B-LSD.svg skin-invert-image 200px 1B-LSD 3D.png bg-transparent 200px Oral Serotonergic psychedelic; Hallucinogen S8 F2 Unscheduled NpSG PSA Unscheduled (may be covered by the Federal Analogue Act if sold for human consumption) Unscheduled 2349376-12-9 145875086 82827098 Y6JQX3L6LP 1-Butyryl-LSD; X-LSD (6aR,9R)-N,N-diethyl-6-methyl-4-butanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide 24 31 3 2 CN1[C@](C2=C[C@@H](C(N(CC)CC)=O)C1)([H])CC3=CN(C(CCC)=O)C4=C3C2=CC=C4 1S/C24H31N3O2/c1-5-9-22(28)27-15-16-13-21-19(18-10-8-11-20(27)23(16)18)12-17(14-25(21)4)24(29)26(6-2)7-3/h8,10-12,15,17,21H,5-7,9,13-14H2,1-4H3/t17-,21-/m1/s1 SVRFNPSJPIDUBC-DYESRHJHSA-N
1B-LSD, also known as 1-butyryl-LSD, is a psychedelic drug of the lysergamide family and an acylated derivative of lysergic acid diethylamide (LSD) which has been sold as a designer drug. Tsochatzis E, Lopes JA, Reniero F, Holland M, Åberg J, Guillou C Identification of 1-Butyl-Lysergic Acid Diethylamide (1B-LSD) in Seized Blotter Paper Using an Integrated Workflow of Analytical Techniques and Chemo-Informatics Molecules 25 3 712 February 2020 32045999 7037844 10.3390/molecules25030712 free
Use and effects
LSD#Uses LSD#Effects
Interactions
Psychedelic drug#Interactions Trip killer#Serotonergic psychedelic antidotes
Pharmacology
Pharmacodynamics
1B-LSD has been found to produce psychedelic-like effects in rodents similarly to LSD, though with only around 1/7 the potency of LSD itself.6 Wagmann L, Richter LH, Kehl T, Wack F, Bergstrand MP, Brandt SD, Stratford A, Maurer HH, Meyer MR July 2019 In vitro metabolic fate of nine LSD-based new psychoactive substances and their analytical detectability in different urinary screening procedures http://researchonline.ljmu.ac.uk/id/eprint/9841/13/ABC-01967-2018_02_accepted.pdf Analytical and Bioanalytical Chemistry 411 19 4751–4763 10.1007/s00216-018-1558-9 30617391 586154186 Brandt SD, Kavanagh PV, Westphal F, Stratford A, Elliott SP, Dowling G, Wallach J, Halberstadt AL August 2019 Return of the lysergamides. Part V: Analytical and behavioural characterization of 1-butanoyl-d-lysergic acid diethylamide (1B-LSD) Drug Testing and Analysis 11 8 1122–1133 10.1002/dta.2613 6899222 31083768 Halberstadt AL, Chatha M, Klein AK, McCorvy JD, Meyer MR, Wagmann L, Stratford A, Brandt SD 6 Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD) Neuropharmacology 172 107856 August 2020 31756337 10.1016/j.neuropharm.2019.107856 9191647 208155327 https://researchonline.ljmu.ac.uk/id/eprint/11815/1/NEUROPHARM-D-19-00561R1_accepted_uncorrected.pdf
Chemistry
Analogues
Related compounds include 1cP-LSD, 1P-LSD, 1V-LSD, ALD-52 (1A-LSD), 1cP-AL-LAD, AL-LAD, ETH-LAD, 1P-ETH-LAD, PRO-LAD, LSM-775, and LSZ, among others.
Society and culture
Legal status
Canada
1B-LSD is not a controlled substance in Canada as of 2025.Controlled Drugs and Substances Act Department of Justice Canada https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html 19 January 2026
Singapore
1B-LSD is illegal in Singapore.Misuse of Drugs Act - Singapore Statutes Online https://sso.agc.gov.sg/Act/MDA1973 sso.agc.gov.sg Sweden's public health agency suggested classifying 1B-LSD as a hazardous substance, on June 24, 2019.https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2019/juni/atta-amnen-foreslas-klassas-som-narkotika-eller-halsofarlig-vara/ Åtta ämnen föreslås klassas som narkotika eller hälsofarlig vara Folkhälsomyndigheten sv 24 June 2019 29 May 2020 18 November 2019 https://web.archive.org/web/20191118191453/https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2019/juni/atta-amnen-foreslas-klassas-som-narkotika-eller-halsofarlig-vara/ dead
United States
1B-LSD is not an explicitly controlled substance in the United States. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) January 2026 U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division United States https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.
See also
Substituted lysergamide
Lizard Labs
References
External links
1B-LSD - Isomer Design
1B-LSD - PsychonautWiki
The Small & Handy 1-Bu-LSD Thread - Bluelight
1B-LSD - Psychedelic Science Review
What is 1B-LSD? The World of LSD Analogs - TripSitter
1B-LSD - Lysergamide Psychedelics - TripSitter
Category:5-HT2A agonists
Category:Designer prodrugs
Category:Diethylamides
Category:Lizard Labs
Category:Psychedelic lysergamides
Category:Serotonin receptor agonists