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1DD-LSD
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Chemical compound
1DD-LSD.svg skin-invert-image 250px 1DD-LSD 3D.png bg-transparent 250px Oral Serotonergic psychedelic; Hallucinogen correct CAS 3028949-80-3 correct FDA 170763787 1-Dodecanoyl-LSD; SYN-L-004 (6aR,9R)-N,N-diethyl-6-methyl-4-dodecanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide 32 47 3 2 CCCCCCCCCCCC(=O)N1C=C2C[C@@H]3C(=C[C@H](CN3C)C(=O)N(CC)CC)C4=C2C1=CC=C4 1S/C32H47N3O2/c1-5-8-9-10-11-12-13-14-15-19-30(36)35-23-24-21-29-27(26-17-16-18-28(35)31(24)26)20-25(22-33(29)4)32(37)34(6-2)7-3/h16-18,20,23,25,29H,5-15,19,21-22H2,1-4H3/t25-,29-/m1/s1 CEPIQEJKLWHRTL-VAVYLYDRSA-N
1DD-LSD, also known as 1-dodecanoyl-LSD or as SYN-L-004, is an acylated derivative of lysergic acid diethylamide (LSD). In animal studies, it produces a weak head-twitch response but with 27x lower potency than LSD itself. It is being researched as a potential slow-onset, long lasting prodrug for LSD which is expected to have reduced psychoactive effects. Kavanagh PV, Westphal F, Pulver B, Elliott SP, Stratford A, Halberstadt AL, Brandt SD Analytical and behavioral characterization of 1-dodecanoyl-LSD (1DD-LSD) Drug Testing and Analysis 17 1 101–109 April 2024 38569566 10.1002/dta.3691 free 11730435 WO 2024/028495 Stratford A, Williamson JP Synex Holdings BV Prodrugs of Substituted Ergolines https://patents.google.com/patent/WO2024028495A1/ 8 February 2024
Use and effects
LSD#Uses LSD#Effects
Interactions
Psychedelic drug#Interactions Trip killer#Serotonergic psychedelic antidotes
Chemistry
Analogues
Analogues of 1DD-LSD include ALD-52 (1A-LSD), 1P-LSD, 1B-LSD, 1H-LSD, and 1V-LSD, among others.
Society and culture
Legal status
Canada
1DD-LSD is not a controlled substance in Canada as of 2025.Controlled Drugs and Substances Act Department of Justice Canada https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html 19 January 2026
United States
1DD-LSD is not an explicitly controlled substance in the United States. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) January 2026 U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division United States https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.
See also
Substituted lysergamide
Lizard Labs
References
External links
1DD-LSD - Isomer Design
Category:Designer prodrugs
Category:Diethylamides
Category:Lizard Labs
Category:Psychedelic lysergamides
Category:Serotonin receptor agonists