2-oxoglutaramate amidase

Class of enzymes 2-oxoglutaramate amidase 3.5.1.111 2-oxoglutaramate amidase (3.5.1.111, omega-amidase) is an enzyme characterised from bacteria with systematic name 5-amino-2,5-dioxopentanoate amidohydrolase.3.5.1.111 It catalyses the hydrolysis of 2-oxoglutaramic acid to α-ketoglutaric acid and ammonia: Cobzaru C, Ganas P, Mihasan M, Schleberger P, Brandsch R Homologous gene clusters of nicotine catabolism, including a new ω-amidase for α-ketoglutaramate, in species of three genera of Gram-positive bacteria Research in Microbiology 162 3 285–91 April 2011 21288482 10.1016/j.resmic.2011.01.001 50% Q27104163 2-oxoglutaramic acid H2O NH3 α-Ketoglutaric acid α-ketoglutaric acid The enzyme is part of the nicotine degradation pathway.Mihăşan Marius Babii Cornelia Aslebagh Roshanak Channaveerappa Devika Dupree Emmalyn Darie Costel C. Proteomics based analysis of the nicotine catabolism in Paenarthrobacter nicotinovorans pAO1 Scientific Reports 2018 8 1 16239 10.1038/s41598-018-34687-y free 30390017 6214936 Mihăşan Marius Babii Cornelia Aslebagh Roshanak Channaveerappa Devika Dupree Emmalyn J. Darie Costel C. Advancements of Mass Spectrometry in Biomedical Research Exploration of Nicotine Metabolism in Paenarthrobacter nicotinovorans pAO1 by Microbial Proteomics Advances in Experimental Medicine and Biology 2019 1140 515–529 10.1007/978-3-030-15950-4_30 31347068 978-3-030-15949-8 References External links 2-oxoglutaramate+amidase Biology no Category:EC 3.5.1