1-Aminomethyl-6-methoxytetralin

vanc 6 AMMT 1-Aminomethyl-6-methoxytetralin.svg skin-invert-image 225px Serotonin reuptake inhibitor None 88631-10-1 10797800 8973106 AMMT (6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)methanamine 12 17 1 1 COC1=CC2=C(C=C1)C(CCC2)CN 1S/C12H17NO/c1-14-11-5-6-12-9(7-11)3-2-4-10(12)8-13/h5-7,10H,2-4,8,13H2,1H3 PWCAWOYQXQCEEV-UHFFFAOYSA-N 1-Aminomethyl-6-methoxytetralin (AMMT) is a serotonin reuptake inhibitor (SRI) of the phenethylamine family. Trachsel D, Lehmann D, Enzensperger C 2013 Phenethylamine: von der Struktur zur Funktion de Nachtschatten-Verlag 1 978-3-03788-700-4 https://books.google.com/books?id=-Us1kgEACAAJ 13 November 2025 https://web.archive.org/web/20251113135159/https://books.google.com/books?id=-Us1kgEACAAJ Phenethylamines: From Structure to Function Solothurn Nachtschatten-Science 858805226 26 May 2026 bot: unknown Roman DL, Saldaña SN, Nichols DE, Carroll FI, Barker EL Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters The Journal of Pharmacology and Experimental Therapeutics 308 2 679–687 February 2004 14593087 10.1124/jpet.103.057836 Rodríguez GJ, Roman DL, White KJ, Nichols DE, Barker EL Distinct recognition of substrates by the human and Drosophila serotonin transporters The Journal of Pharmacology and Experimental Therapeutics 306 1 338–346 July 2003 12682215 10.1124/jpet.103.048751 Walline CC, Nichols DE, Carroll FI, Barker EL Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition The Journal of Pharmacology and Experimental Therapeutics 325 3 791–800 June 2008 18354055 2637348 10.1124/jpet.108.136200 It is a cyclized phenethylamine and is an analogue of 1-aminomethyl-5-methoxyindane (AMMI). The drug shows weak affinity for the human serotonin transporter (SERT) (Ki = 7,000–18,000nM). AMMT was first described in the scientific literature by David Lance Roman and David E. Nichols and colleagues at Purdue University by 2004. Roman DL 30 November 2005 Molecular determinants of ligand interaction with serotonin transporters Purdue e-Pubs https://docs.lib.purdue.edu/dissertations/AAI3150826/ 26 May 2026 See also Cyclized phenethylamine 1-Aminomethyl-5-methoxyindane (AMMI) 9-Aminomethyl-9,10-dihydroanthracene (AMDA) 2CB7 (2C-B-5-hemiFLY-β7) References External links AMMT - Isomer Design Category:Methoxyphenethylamines Category:Serotonin reuptake inhibitors Category:Tetralins