2,6-Dimethylmescaline

vanc 6 2,6-Dimethylmescaline.svg skin-invert-image 235px Serotonin receptor modulator None DMe-M; Dimethylmescaline; 2,6-Dimethyl-3,4,5-trimethoxyphenethylamine; 3,4,5-Trimethoxy-2,6-dimethylphenethylamine 2-(3,4,5-trimethoxy-2,6-dimethylphenyl)ethan-1-amine 13 21 1 3 NCCc1c(C)c(OC)c(c(c1C)OC)OC 1S/C13H21NO3/c1-8-10(6-7-14)9(2)12(16-4)13(17-5)11(8)15-3/h6-7,14H2,1-5H3 VUZBXFVHLMPADZ-UHFFFAOYSA-N 2,6-Dimethylmescaline, or simply dimethylmescaline (DMe-M), also known as 2,6-dimethyl-3,4,5-trimethoxyphenethylamine, is a serotonin receptor modulator of the phenethylamine and scaline families related to mescaline. Trachsel D, Lehmann D, Enzensperger C Phenethylamine: von der Struktur zur Funktion Solothurn 935–936 2013 Phenethylamines: From Structure to Function 1 Nachtschatten-Verlag Nachtschatten-Science 978-3-03788-700-4 858805226 https://books.google.com/books?id=-Us1kgEACAAJ de https://web.archive.org/web/20251113135159/https://books.google.com/books?id=-Us1kgEACAAJ 13 November 2025 26 November 2025 bot: unknown It is the 2,6-dimethyl derivative of mescaline. The drug shows affinity for the serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors (Ki = 45nM, 879nM, and 1,002nM, respectively). These affinities were 66-fold, 5.2-fold, and 7.7-fold higher than those of mescaline, respectively. The drug has not been tested in animals or humans. 2,6-Dimethylmescaline was first described in the scientific literature by Daniel Trachsel and colleagues in 2013. The source of the information cited by Trachsel and colleagues was a personal communication with David E. Nichols in 2010. It is not a controlled substance in Canada as of 2025.Controlled Drugs and Substances Act Department of Justice Canada https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html 19 January 2026 See also Scaline PeMPEA (2,6-dimethoxymescaline) 2,6-Dibromomescaline 2,6-Dichloromescaline DOTMA (Julia; 3,6-dimethyl-DOM) Juno (6-methyl-DOM) Ganesha (3-methyl-DOM) Mescaline-FLY References External links Dimethylmescaline (2,6-Dimethylmescaline) - Isomer Design Category:Daniel Trachsel Category:David E. Nichols Category:Methyl compounds Category:Scalines Category:Serotonin receptor modulators