2-hydroxymethylglutarate dehydrogenase

In enzymology, 2-hydroxymethylglutarate dehydrogenase (EC 1.1.1.291) is an enzyme that catalyzes the chemical reaction The two substrates of this enzyme are (S)-2-hydroxymethylglutaric acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 2-formylglutaric acid, reduced NADH, and a proton. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2-hydroxymethylglutarate:NAD+ oxidoreductase. This enzyme is also called HgD. == References ==